Principal Scientist Quantitative Systems
Company: Sanofi
Location: Cambridge
Posted on: July 2, 2025
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Job Description:
Job Description Job Title: Principal Scientist Quantitative
Systems Location: Waltham, MA About the Job Are you ready to shape
the future of medicine? The race is on to speed up drug discovery
and development to find answers for patients and their families.
Your skills could be critical in helping teams accelerate Progress.
Join our Quantitative Systems Pharmacology (QSP) group as a
Principal Scientist and you'll support our R&D portfolio with
mechanistic disease modeling. This position is based in Cambridge,
MA. We are an innovative global healthcare company with one
purpose: to chase the miracles of science to improve people’s
lives. We’re also a company where you can flourish and grow your
career, with countless opportunities to explore, make connections
with people, and stretch the limits of what you thought was
possible. Ready to get started?? Main Responsibilities: - Function
as part of a team to develop and apply multiscale computational
models of complex diseases based on detailed biological mechanistic
knowledge to support model-informed drug discovery & development. -
Survey literature to gain understanding of critical physiological
processes to be represented, and identify suitable mechanistic
elements, data, parameters and assumptions to be included. -
Identify and analyze suitable internal preclinical and clinical
data to inform modeling activities. - Analyze simulation results
and identify appropriate strategies to resolve issues pertaining to
model performance and accuracy. - Maintain extensive documentation
of model development process, and data analysis. - Maintain
quantitative systems pharmacology expertise through comprehensive
education. - Communicate modeling predictions to key stakeholders.
About You: - PhD with an excellent track record of productivity in
the areas of systems pharmacology/biology, computational biology,
biomedical engineering or related field, as manifested by
publications and scientific presentations in conferences. - At
least 2 years of Postdoctoral experience in disease modeling/QSP. -
Experience in drug discovery/development a plus, especially in
bioinformatics or pharmacometrics. - Proficiency in mathematical
modeling using differential equations. - Extensive experience in
computational tools such as MATLAB, Julia and R (MATLAB preferred).
- Excellent oral and written communication skills. - Ability to
quickly learn pathophysiology in indications of interest, and
treatment approaches in immunology. - Highly motivated,
detail-oriented, and independent researcher. - Able to thrive in a
collaborative, multi-disciplinary team environment. - Strong
commitment to on-the-job-training. - Preferred but no required:
Knowledge of Immunology Why Choose Us? - Bring the miracles of
science to life alongside a supportive, future-focused team. -
Discover endless opportunities to grow your talent and drive your
career, whether it’s through a promotion or lateral move, at home
or internationally. - Enjoy a thoughtful, well-crafted rewards
package that recognizes your contribution and amplifies your
impact. - Take good care of yourself and your family, with a wide
range of health and wellbeing benefits including high-quality
healthcare, prevention and wellness programs and at least 14 weeks’
gender-neutral parental leave. Sanofi Inc. and its U.S. affiliates
are Equal Opportunity and Affirmative Action employers committed to
a culturally diverse workforce. All qualified applicants will
receive consideration for employment without regard to race; color;
creed; religion; national origin; age; ancestry; nationality;
marital, domestic partnership or civil union status; sex, gender,
gender identity or expression; affectional or sexual orientation;
disability; veteran or military status or liability for military
status; domestic violence victim status; atypical cellular or blood
trait; genetic information (including the refusal to submit to
genetic testing) or any other characteristic protected by law.
GD-SA ? LI-SA LI-Onsite vhd All compensation will be determined
commensurate with demonstrated experience. Employees may be
eligible to participate in Company employee benefit programs, and
additional benefits information can be found here.
Keywords: Sanofi, New Bedford , Principal Scientist Quantitative Systems, Science, Research & Development , Cambridge, Massachusetts
